Scalable robotic biofabrication of tissue spheroids

Biofabrication of Tissue Scaffolds

3D biofabrication strategies for tissue engineering and regenerative medicine.

Over the past several decades, there has been an ever-increasing demand for organ transplants. However, there is a severe shortage of donor organs, and as a result of the increasing demand, the gap between supply and demand continues to widen. A potential solution to this problem is to grow or fabricate organs using biomaterial scaffolds and a person's own cells. Although the realization of thi...

Auricular reconstruction using biofabrication-based tissue engineering strategies.

Auricular malformations, which impose a significant social and psychological burden, are currently treated using ear prostheses, synthetic implants or autologous implants derived from rib cartilage. Advances in the field of regenerative medicine and biofabrication provide the possibility to engineer functional cartilage with intricate architectures and complex shapes using patient-derived or do...

Biofabrication and Bone Tissue Regeneration: Cell Source, Approaches, and Challenges

The growing occurrence of bone disorders and the increase in aging population have resulted in the need for more effective therapies to meet this request. Bone tissue engineering strategies, by combining biomaterials, cells, and signaling factors, are seen as alternatives to conventional bone grafts for repairing or rebuilding bone defects. Indeed, skeletal tissue engineering has not yet achiev...

Scalable Control of Distributed Robotic Macrosensors

This paper describes a control mechanism by which large numbers of inexpensive robots can be deployed as a distributed remote sensing instrument, and in which the desired large-scale properties of the sensing instrument emerge from the simple pair-wise interactions of its component robots. Such sensing instruments are called distributed robotic macrosensors. Robots in the macrosensor interact w...